ABSTRACT
This present study was aimed to observe under the research grade compound light microscope thehisto-toxicological effects manifested post-application of 10% and 20% solutions of aluminium nitratethat was topically applied onto the outermost surface of the ear integument of 24 Albino rabbitstreated daily. The animals were then divided into two groups comprising of 12 experimental and 12controls. Initially right sided test areas were excised of the experimental and control animals after 15days of application to observe immediate effects, whereas the left sided test areas of the animalswere kept for another month without any further treatment and then excised on day 45 to elucidateits delayed effects. The results revealed histological features of a thickened epidermis withhyperkeratosis, acanthosis and the presence of epidermal micro-abscesses. The dermis showedfeatures of edema, increase in vascularity, decrease in sweat and sebaceous glands and infiltration ofinflammatory cells.It was significantly noted that the histological features were far more severelymanifested in the integument applied with 20% w/v solution as compared to that applied with 10% w/v solution. However these changes persisted in a moderate form following discontinuation of aluminiumnitrate application.